Effectiveness of Generic Levitra is not decreasing with time, ensuring reliable results time after time.
In 91% of men indicated the normalization of erectile function after the initial dose of Generic Levitra 10 mg.
Generic Levitra takes effect within 10 minutes after ingestion, allowing you to realize the desire to quickly and naturally.
The optimal duration of Generic Levitra is 8 - 12 hours, thus providing full sexual intercourse, at all times, an increase of potency.
High security is achieved high selectivity against FDE-5.
Eating and drinking do not affect the efficiency of Generic Levitra. Generic Levitra is well tolerated and convenient to use.
Pharmacological properties
Pharmacodynamics
Erection of the penis is a hemodynamic process that is based on the relaxation of smooth muscles of cavernous bodies and located in the arterioles. During sexual stimulation of the nerve endings cavernous bodies allocated nitric oxide (N0), activating the enzyme guanilattsiklazu, which leads to higher content of cyclic guanozinmonofosfata cavernous bodies (tsGMF). The result is a relaxation of smooth muscles of cavernous bodies, which contributes to increase the flow of blood to the penis.
Blocking fosfodiesterazu specifics fifth type (FDE5) involved in the decomposition of tsGMF, Generic Levitra thereby increases the local action of endogenous nitric oxide (N0) in the cavernous body during sexual stimulation. This effect leads to the ability to Generic Levitra enhance response to sexual stimulation.
Pharmacokinetics
After ingestion Generic Levitra rapidly absorbed and takes effect in 15 minutes (for the majority of men after 25 minutes) with a duration of 4-5 hours.
Indications for use
Erectile dysfunction (inability to attain and to maintain erection required for the commission of sexual intercourse).
Contraindications
Hypersensitivity to any component of the drug.
The simultaneous use of nitrates or drugs that are the donor of nitric oxide.
The combination of HIV protease inhibitors such as indinavir or ritonavir.
Generic Levitra does not show the women and children under 16 years of age.
With caution should be used in patients:
-with the lengthening of the interval from birth;
-with anatomical deformation of the penis (curvature, cavernous fibrosis, a disease Peyroni);
diseases predispose to priapizmu (sickle-cell anemia, multiple myeloma, leukemia);
-with severe liver dysfunction. Patients with minor liver dysfunction change the dosage is not required. In patients with moderate liver dysfunction starting dose is 5 mg per day. In the future, depending on the efficiency and portability of the treatment dose can be increased to a maximum of 10 mg;
-with kidney disease in the terminal stage. In patients with low, moderate and severe decline in renal function change the dosage is not required;
-with arterial hypotension (systolic pressure at rest below 90 mm Hg. Art.)
recently transferred to the stroke and myocardial infarction, with unstable angina;
-with hereditary retinal degenerative diseases (such as retinitis pigmentosa);
-with a penchant for bleeding and exacerbation of peptic ulcer disease;
-with aortic stenosis and idiopathic hypertrophic subaortalnym stenosis.
Dosing and Administration
Initial dose is 10 mg. Agreed for 25-60 minutes before sex.
Generic Levitra duration of action is 5-6 hours.
The maximum recommended frequency of dose reduction - 1 times a day. Depending on the efficiency and portability of the treatment dose can be increased to 20 mg or decreased to 5 mg per day.
The maximum recommended dose is 20 mg 1 time a day.
Dose 5 mg is recommended for older patients (over 65).
20mg dose is assigned in cases of severe ED (diabetes, prostatektomiya) when the starting dose of 10 mg is insufficient.
Eating and drinking do not affect the effectiveness of Generic Levitra.
Generic Levitra is effective only when a sufficient level of sexual stimulation.
Side Effects
Generic Levitra as a whole is moved well, side effects are usually slightly or moderately raised and are transient in nature.
The most common (1-10%): Headache, redness of face, indigestion, nausea, dizziness, rhinitis.
Atypical and rare (0,1-1%): face edema, photosensitization, pain, hypertension, changes in the functional "liver" tests, increased GGTP, increased kreatinkinazy, mialgiya, drowsiness, dyspnea, visual impairment, running eyes , priapizm, anaphylactic reaction (including laryngeal edema), angina pectoris, arterial hypotension, myocardial ischemia, postural hypotension, sinkopalnye state, increasing muscle tone, nasal bleeding, glaucoma.
Overdosage
Known cases of receiving Generic Levitra in dose of 80 mg per day, which is not accompanied by serious adverse reactions. However, at the same time when applying for a dose of 40 mg twice a day, there are expressed in lumbar pain without signs of toxic effect on the muscle and nervous system.
Interaction with other drugs
Dose Generic Levitra should not exceed 5 mg when combined with erythromycin, ketokonazolom, itrakonazolom. Dose ketokonazola and itrakonazola does not exceed 200 mg. The combination of indinavir and ritonavir contraindicated.
Nitrates, donor of nitric oxide: combined appointment Generic Levitra and nitrates contraindicated because of the risk of development of arterial hypotension.
Combining therapy of alpha-adrenoblokatorami and Generic Levitra may be accompanied by the development of arterial hypotension. Generic Levitra should be applied not earlier than 6 hours after administration of alpha-adrenoblokatorov and its dose should not exceed 5 mg. However, when combined with alpha-blockers tamsulozinom, administration of drugs over time may be the same.
